PubMed Buddy is a GPT that offers an innovative way to explore scientific literature. It is designed to enable comprehensive and conversational interactions with both PubMed and the UnPaywall database. With the capability to access these two robust database sources, PubMed Buddy aids researchers and scholars in their quest to seek relevant and targeted literature on their topics of interest.This GPT provides not only an avenue to discover and navigate through extensive bibliographic information in PubMed but also facilitates direct access to full-text articles housed in the UnPaywall database. This dual access approach enhances the efficiency of academic literature reviews and research processes. PubMed Buddy thrives on user interaction. It considers specific search preferences and optimizes queries based on user-provided research topics, search criteria, specific research areas, keywords, or terms. It allows for personalized and tailored searches enabling users to zone in on the most pertinent information related to their investigation. In essence, PubMed Buddy can change the landscape of academic research by making literature exploration more intuitive and conversational. As a GPT, its integration with the powerful ChatGPT enhances the user's experience by providing tools to chat with the system in a collaborative, interactive manner. This takes the experience beyond a traditional research tool into an engaging, productive conversation with AI, helping users uncover valuable scholarly content in a more conversational and user-friendly way.